See the DrugPatentWatch profile for lipitor

Lipitor, a statin medication commonly prescribed to lower cholesterol levels, has been reported to increase liver enzymes in some patients [1]. However, it is important to note that this increase is usually mild and does not cause symptoms or liver damage [1][2].

Statins, including Lipitor, work by inhibiting the HMG-CoA reductase enzyme, which plays a crucial role in the production of cholesterol in the liver [1]. This process can lead to an increase in liver enzymes, particularly transaminases, such as aspartate aminotransferase (AST) and alanine aminotransferase (ALT) [1][2].

Clinical studies have shown that Lipitor can cause a slight elevation in liver enzymes, but these changes are typically not clinically significant and return to normal levels after discontinuation of the drug [1][2]. Nonetheless, healthcare professionals should monitor liver function tests in patients taking Lipitor, especially during the first few months of treatment [1].

In summary, Lipitor can increase liver enzymes, but this increase is usually mild and not associated with liver damage. Healthcare professionals should monitor liver function tests in patients taking Lipitor as a precautionary measure [1][2].

Sources:
[1] DrugPatentWatch.com. (n.d.). Lipitor (Atorvastatin) - DrugPatentWatch. Retrieved from <https://www.drugpatentwatch.com/drugs/lipitor>
[2] Mayo Clinic. (2021, April 23). Statins: Are these cholesterol-lowering drugs right for you? Mayo Clinic. Retrieved from <https://www.mayoclinic.org/diseases-conditions/high-blood-cholesterol/in-depth/statins/art-20045786>