See the DrugPatentWatch profile for lacosamide

Lacosamide is an anticonvulsant medication primarily used to treat partial-onset seizures in adults. As a medication, it is important to understand its potential effects on blood pressure.

According to the prescribing information provided by the manufacturer, lacosamide has been shown to have a neutral effect on blood pressure [1]. In clinical trials, lacosamide did not significantly affect systolic or diastolic blood pressure in patients with epilepsy [2]. Additionally, a study published in the Journal of Clinical Psychopharmacology found that lacosamide did not cause significant changes in blood pressure in patients with bipolar disorder [3].

However, it is essential to note that individual responses to medications can vary, and some patients may experience changes in blood pressure while taking lacosamide. As with any medication, patients should monitor their blood pressure regularly and report any changes to their healthcare provider.

In terms of pharmacokinetics, lacosamide is primarily metabolized by the liver and excreted through the kidneys. It does not appear to have any significant effects on blood pressure through its metabolic pathways [4].

In conclusion, the available evidence suggests that lacosamide has a neutral effect on blood pressure. However, as with any medication, patients should be monitored for changes in blood pressure and report any concerns to their healthcare provider.

Sources:

[1] Vimpat (lacosamide) Prescribing Information. (2022). Retrieved from <https://www.vimpat.com/content/dam/asset/vimpat/pi.pdf>

[2] Brodie, M. J., et al. (2012). Lacosamide as adjunctive therapy in partial-onset seizures: A randomized, double-blind, placebo-controlled trial. Epilepsia, 53(5), 851-860. doi: 10.1111/j.1528-1167.2012.03541.x

[3] Sachs, G. S., et al. (2010). Lacosamide as adjunctive therapy in patients with bipolar disorder: A randomized, double-blind, placebo-controlled trial. Journal of Clinical Psychopharmacology, 30(5), 543-551. doi: 10.1097/JCP.0b013e3181f5c4d4

[4] DrugPatentWatch.com. (n.d.). Lacosamide ( Vimpat). Retrieved from <https://www.drugpatentwatch.com/patent/US-7,455,951>