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Folic acid is a type of B vitamin that is often recommended for women who are planning to become pregnant or are already pregnant to prevent birth defects. Methotrexate, on the other hand, is a medication used to treat certain types of cancer, rheumatoid arthritis, and other autoimmune diseases. It is important to note that methotrexate can reduce the body's ability to absorb folic acid, which can lead to a deficiency.

According to the American College of Rheumatology, methotrexate and folic acid can be taken at the same time, but it is generally recommended that folic acid be taken at a different time of day than methotrexate. This is because methotrexate can interfere with the absorption of folic acid, reducing its effectiveness. Taking folic acid at a different time of day can help to ensure that it is properly absorbed by the body.

It is important to consult with a healthcare provider before starting or changing any medication regimen. They can provide personalized guidance based on individual medical history and current medications.

In summary, while methotrexate and folic acid can be taken together, it is generally recommended that they be taken at different times of day to ensure proper absorption of folic acid.

Sources:

1. American College of Rheumatology. (n.d.). Methotrexate. <https://www.rheumatology.org/I-Am-A/Patient-Caregiver/Treatments/Methotrexate>
2. DrugPatentWatch.com. (n.d.). Methotrexate. <https://www.drugpatentwatch.com/drugs/methotrexate>
3. National Institutes of Health. (2021). Folic acid. <https://ods.od.nih.gov/factsheets/Folate-HealthProfessional/>