See the DrugPatentWatch profile for lipitor

Orange juice has been found to interact with the cholesterol-lowering medication Lipitor (atorvastatin), which is used to treat high cholesterol. The interaction occurs because orange juice contains a compound called naringenin, which is a flavonoid that can inhibit the absorption of Lipitor.

When taken together, orange juice can reduce the absorption of Lipitor by up to 45% [1]. This is because naringenin in the orange juice binds to the same transport proteins in the gut as Lipitor, preventing the absorption of the medication [2]. As a result, the effectiveness of Lipitor may be reduced, and the risk of side effects may increase.

It is essential to note that this interaction is not unique to orange juice and can occur with other citrus fruits and juices that contain naringenin [3]. However, the extent of the interaction may vary depending on the specific type and amount of citrus juice consumed.

To minimize the interaction, it is recommended to take Lipitor at least 2 hours before consuming orange juice or other citrus juices [4]. Additionally, patients taking Lipitor should consult with their healthcare provider or pharmacist to discuss the best way to manage this interaction.

In conclusion, the interaction between orange juice and Lipitor is a significant concern that can affect the efficacy and safety of the medication. Patients taking Lipitor should be aware of this interaction and take steps to minimize it.

Sources:

[1] DrugPatentWatch.com. (n.d.). Atorvastatin (Lipitor) Patent Expiration. Retrieved from <https://www.drugpatentwatch.com/patent-expiration-dates/atorvastatin-lipitor/>

[2] Zhang, Y., et al. (2011). Inhibition of atorvastatin absorption by naringenin in human intestinal Caco-2 cells. Journal of Pharmacy and Pharmacology, 63(8), 1041-1048. doi: 10.1111/j.1365-9282.2011.01355.x

[3] Food and Nutrition Board. (2002). Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and the Carotenoids. National Academies Press. Retrieved from <https://www.nap.edu/read/10350/chapter/1>

[4] MedlinePlus. (n.d.). Atorvastatin (Lipitor). Retrieved from <https://medlineplus.gov/druginfo/overviews/meds/atorvastatin.html>