Based on the information available, there is no definitive answer as to whether Lipitor should be taken with or without probiotics. According to Drugs.com, Lipitor (atorvastatin) is a medication used to treat high cholesterol and prevent heart disease [1]. The drug works by reducing the amount of cholesterol produced by the liver. On the other hand, probiotics are live bacteria and yeasts that are good for your health, especially your digestive system [2].

While there is some research suggesting that probiotics may help lower cholesterol levels [3], it is unclear if taking probiotics with Lipitor would enhance its effectiveness or cause any adverse interactions. Drugs.com does not list probiotics as a drug interaction for Lipitor [1]. However, it is always recommended to consult with a healthcare provider before starting any new supplement or medication regimen.

In summary, there is no clear answer as to whether Lipitor should be taken with or without probiotics. While probiotics may help lower cholesterol levels, it is unclear if they interact with Lipitor. As always, consult with a healthcare provider before starting any new supplement or medication regimen.

Sources:

1. [Drugs.com](https://www.drugs.com/lipitor.html)
2. [Mayo Clinic](https://www.mayoclinic.org/what-are-probiotics/art-20232594)
3. [National Center for Complementary and Integrative Health](https://www.nccih.nih.gov/health/probiotics-what-you-need-to-know)
4. [DrugPatentWatch.com](https://www.drugpatentwatch.com/drugs/lipitor)