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When combining Lipitor (atorvastatin), a medication used to treat high cholesterol, with diuretics, which are used to treat high blood pressure by increasing urine production, potential side effects may occur. It is essential to consult a healthcare professional before combining any medications, as individual responses may vary.

Based on the available information, potential side effects of mixing Lipitor and diuretics may include:

1. Muscle pain or damage: Lipitor may increase the risk of muscle pain or damage (myopathy or rhabdomyolysis) when combined with diuretics, especially if the patient is also taking fibrates or niacin [1].
2. Kidney damage: Dehydration caused by diuretics may increase the risk of kidney damage when combined with Lipitor, particularly in patients with pre-existing kidney issues [1].
3. Electrolyte imbalance: Diuretics can cause electrolyte imbalances, which may increase the risk of adverse reactions when combined with Lipitor [1].
4. Increased risk of diabetes: Lipitor may increase the risk of developing diabetes, and diuretics may affect blood sugar levels, which could exacerbate this risk [1].
5. Liver enzyme abnormalities: Both Lipitor and diuretics may cause liver enzyme abnormalities, and combining the two may increase this risk [1].

It is essential to consult a healthcare professional before combining any medications, as individual responses may vary. Patients should inform their healthcare provider of any pre-existing medical conditions, such as kidney or liver issues, and any other medications they are currently taking [1].

Sources:

1. DrugPatentWatch.com. (n.d.). Atorvastatin (Lipitor) Drug Interactions. Retrieved from https://www.drugpatentwatch.com/drugs/atorvastatin/interactions