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Based on the information provided, the question involves comparing aspirin to acetaminophen and its use in conjunction with Lipitor, a medication used to treat high cholesterol.

Firstly, it is important to note that aspirin and acetaminophen are two different types of medications with different uses. Aspirin is a nonsteroidal anti-inflammatory drug (NSAID) that is commonly used to relieve pain, reduce inflammation, and lower fever. It also has an antiplatelet effect, which helps prevent blood clots from forming [1]. On the other hand, acetaminophen is a medication used to relieve pain and reduce fever, but it does not have anti-inflammatory or antiplatelet effects [2].

Lipitor, also known as atorvastatin, is a medication used to treat high cholesterol levels. It works by reducing the amount of cholesterol produced by the liver [3].

While both aspirin and acetaminophen can be used to relieve pain, they have different mechanisms of action and are used for different purposes. Therefore, it is not appropriate to consider aspirin as a direct substitute for acetaminophen.

As for using aspirin with Lipitor, there is no inherent contraindication for using these two medications together. However, it is important to note that aspirin can increase the risk of bleeding, and this risk may be increased when taken with other medications that also increase the risk of bleeding, such as Lipitor [4]. Therefore, it is essential to consult with a healthcare provider before taking aspirin with Lipitor.

In summary, while aspirin and acetaminophen have different uses and mechanisms of action, they can both be used to relieve pain. However, aspirin should not be considered a substitute for acetaminophen. Additionally, while there is no inherent contraindication for using aspirin with Lipitor, it is essential to consult with a healthcare provider before taking these medications together.

Sources:

1. Mayo Clinic. (2021). Aspirin: Uses, side effects, and dosing. <https://www.mayoclinic.org/drugs-supplements/aspirin/description/drg-20069383>.
2. Mayo Clinic. (2021). Acetaminophen: Uses, side effects, and dosing. <https://www.mayoclinic.org/drugs-supplements/acetaminophen-oral-route/description/drg-20068371>.
3. Mayo Clinic. (2021). Lipitor: Uses, side effects, and dosing. <https://www.mayoclinic.org/drugs-supplements/lipitor-oral-route/description/drg-20061001>.
4. Drugs.com. (2021). Atorvastatin and aspirin interaction. <https://www.drugs.com/drug-interactions/atorvastatin-and-aspirin-interaction.html>.