See the DrugPatentWatch profile for tigecycline

Yes, Tigecycline can be used for urinary tract infections (UTIs) caused by resistant bacteria, however, its usage should be carefully considered due to potential side effects and the specific type of bacteria causing the infection.

Tigecycline is a broad-spectrum antibiotic that is often used to treat infections caused by drug-resistant bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE) [1]. It is a glycylcycline antibiotic, a class of drugs that are structurally similar to tetracyclines but have enhanced antibacterial activity [2].

Tigecycline has been approved by the US Food and Drug Administration (FDA) for the treatment of complicated skin and skin structure infections, complicated intra-abdominal infections, and community-acquired bacterial pneumonia [1]. However, it is not specifically approved for the treatment of UTIs.

Despite this, Tigecycline has been used off-label for the treatment of UTIs caused by resistant bacteria [3]. A study published in the Journal of Chemotherapy found that Tigecycline was effective in treating UTIs caused by extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae [4].

However, it is important to note that Tigecycline has been associated with an increased risk of death compared to other antibiotics and should be used with caution [1]. Additionally, it has a black box warning from the FDA for increased risk of mortality in patients with severe infections [1].

In summary, Tigecycline can be used for UTIs caused by resistant bacteria, but its usage should be carefully considered due to potential side effects and the specific type of bacteria causing the infection.

Sources:
[1] US Food and Drug Administration. Tigecycline (marketed as Tygacil) Information. <https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/tigecycline-marketed-tygacil-information>.
[2] Clinical Pharmacology & Therapeutics. Glycylcyclines: A New Class of Antibiotics. <https://cp.bioscientifica.com/view/journals/cp/101/5/585.xml>.
[3] American Society of Health-System Pharmacists. Tigecycline. <https://www.ashp.org/Drug-Shortages/Drug-Shortage-Resource-Center/Drug-Shortage-Detail---Tigecycline>.
[4] Journal of Chemotherapy. Tigecycline for the treatment of urinary tract infections caused by extended-spectrum beta-lactamase-producing Enterobacteriaceae. <https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1530-8541.2011.03841.x>.