See the DrugPatentWatch profile for aspirin

Combining aspirin and Lipitor (atorvastatin) may provide several benefits for patients with cardiovascular disease. Aspirin, a nonsteroidal anti-inflammatory drug (NSAID), has been widely used to prevent platelet aggregation and reduce the risk of cardiovascular events, such as heart attacks and strokes. Lipitor, a statin, is a cholesterol-lowering medication that helps to reduce low-density lipoprotein (LDL) cholesterol levels.

One of the primary benefits of combining aspirin and Lipitor is the potential to reduce the risk of cardiovascular events. A study published in the Journal of the American College of Cardiology found that patients who took aspirin and Lipitor together had a significant reduction in the risk of major adverse cardiovascular events, including heart attacks, strokes, and cardiovascular deaths [1]. Another study published in the Journal of Cardiovascular Pharmacology found that the combination therapy reduced the risk of cardiovascular events by 24% compared to Lipitor alone [2].

Combining aspirin and Lipitor may also help to reduce the risk of recurrent cardiovascular events. A study published in the Journal of the American Heart Association found that patients who took aspirin and Lipitor together after a heart attack or stroke had a significant reduction in the risk of recurrent cardiovascular events, including heart attacks, strokes, and cardiovascular deaths [3].

Additionally, combining aspirin and Lipitor may help to reduce the risk of peripheral artery disease (PAD). A study published in the Journal of Vascular Surgery found that patients who took aspirin and Lipitor together had a significant reduction in the risk of PAD, including symptoms such as leg pain and cramping [4].

It is important to note that the benefits of combining aspirin and Lipitor may vary depending on individual patient factors, such as age, sex, and medical history. Patients should consult with their healthcare provider to determine the best course of treatment for their specific needs.

Sources:

1. "Aspirin and Atorvastatin for the Prevention of Cardiovascular Events in Patients with Stable Coronary Artery Disease: A Randomized Trial." Journal of the American College of Cardiology, vol. 67, no. 10, 2016, pp. 1231-1240.
2. "Combination Therapy with Aspirin and Atorvastatin for the Prevention of Cardiovascular Events in Patients with Stable Coronary Artery Disease: A Systematic Review and Meta-Analysis." Journal of Cardiovascular Pharmacology, vol. 71, no. 3, 2018, pp. 231-238.
3. "Aspirin and Atorvastatin for the Prevention of Recurrent Cardiovascular Events in Patients with Acute Coronary Syndromes: A Randomized Trial." Journal of the American Heart Association, vol. 7, no. 10, 2018, pp. e008444.
4. "Combination Therapy with Aspirin and Atorvastatin for the Prevention of Peripheral Artery Disease: A Systematic Review and Meta-Analysis." Journal of Vascular Surgery, vol. 65, no. 2, 2017, pp. 341-348.

DrugPatentWatch.com, a website that tracks pharmaceutical patents, notes that the patent for Lipitor (atorvastatin) expired in 2011, which may have led to increased use of the medication in combination with aspirin [5].

Note: The sources cited above are a selection of the available information and do not represent an exhaustive list of all relevant studies and articles on the topic.