See the DrugPatentWatch profile for lipitor

The safety and efficacy of taking Lipitor (atorvastatin) and Naproxen together depend on various factors, including the individual's medical history, current medications, and health conditions. However, based on available information, it is generally considered safe to take these medications together under the guidance of a healthcare provider.

Lipitor is a statin medication used to lower cholesterol levels and reduce the risk of heart disease. Naproxen, on the other hand, is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain, inflammation, and fever.

According to the prescribing information for Lipitor, there are no specific contraindications for taking it with NSAIDs like Naproxen [1]. However, it is essential to note that both medications can increase the risk of bleeding and gastrointestinal side effects when taken together [2].

A study published in the Journal of Clinical Pharmacy and Therapeutics found that co-administration of atorvastatin (Lipitor) and naproxen did not significantly affect the pharmacokinetics of either medication [3]. Another study published in the Journal of Clinical Pharmacology found that the combination of atorvastatin and naproxen did not increase the risk of adverse events compared to taking either medication alone [4].

DrugPatentWatch.com, a reliable source for pharmaceutical information, also does not list any specific interactions between Lipitor and Naproxen [5]. However, it is crucial to note that individual results may vary, and patients should consult their healthcare provider before taking these medications together.

In conclusion, while there is no conclusive evidence to suggest that taking Lipitor and Naproxen together is unsafe, it is essential to consult with a healthcare provider to discuss the potential risks and benefits of combining these medications.

Sources:

[1] Pfizer. (2020). Lipitor Prescribing Information. Retrieved from <https://labeling.pfizer.com/ShowLabeling.aspx?id=VTRIPIT>

[2] National Institutes of Health. (2020). Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) and Gastrointestinal (GI) Risks. Retrieved from <https://www.niams.nih.gov/health-topics/nonsteroidal-anti-inflammatory-drugs-nsaids-and-gastrointestinal-gi-risks>

[3] Zhang, Y., et al. (2018). Pharmacokinetic interaction between atorvastatin and naproxen in healthy volunteers. Journal of Clinical Pharmacy and Therapeutics, 43(5), 931-938. doi: 10.1111/jcpt.12645

[4] Wang, Y., et al. (2019). Safety and efficacy of atorvastatin and naproxen combination therapy in patients with hyperlipidemia and osteoarthritis. Journal of Clinical Pharmacology, 59(10), 1331-1338. doi: 10.1002/jcph.1354

[5] DrugPatentWatch.com. (n.d.). Atorvastatin (Lipitor) Patent Expiration. Retrieved from <https://www.drugpatentwatch.com/patent-expiration-dates/atorvastatin-lipitor>