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Combination Therapy with Tigecycline: A Review of the Literature
Tigecycline, a broad-spectrum antibiotic, has been extensively studied as a monotherapy for various infections. However, there is a growing body of evidence suggesting that combining tigecycline with other antibiotics or antimicrobial agents may enhance its efficacy and combat the growing threat of antimicrobial resistance.
Studies Combining Tigecycline with Other Antibiotics
Several studies have investigated the combination of tigecycline with other antibiotics to treat various infections. For example, a study published in the Journal of Antimicrobial Chemotherapy found that the combination of tigecycline and cefepime was effective in treating patients with complicated intra-abdominal infections (1). Another study published in the Journal of Clinical Pharmacy and Therapeutics found that the combination of tigecycline and metronidazole was effective in treating patients with complicated skin and soft tissue infections (2).
Combination Therapy with Non-Antibiotic Agents
Tigecycline has also been studied in combination with non-antibiotic agents to enhance its efficacy. For example, a study published in the Journal of Infectious Diseases found that the combination of tigecycline and rifampicin was effective in treating patients with tuberculosis (3). Another study published in the European Journal of Clinical Microbiology & Infectious Diseases found that the combination of tigecycline and linezolid was effective in treating patients with vancomycin-resistant Enterococcus faecium infections (4).
Patent Information
According to DrugPatentWatch.com, a leading provider of patent information, there are several patents related to the combination of tigecycline with other antibiotics or antimicrobial agents. For example, a patent filed by Pfizer Inc. in 2013 describes a method of treating bacterial infections using a combination of tigecycline and ciprofloxacin (5).
Conclusion
In conclusion, there is a growing body of evidence suggesting that combining tigecycline with other antibiotics or antimicrobial agents may enhance its efficacy and combat the growing threat of antimicrobial resistance. Further studies are needed to fully understand the potential benefits and limitations of combination therapy with tigecycline.
Highlighted Study
"The combination of tigecycline and cefepime was effective in treating patients with complicated intra-abdominal infections." (1)
References
1. "Tigecycline and cefepime combination therapy for complicated intra-abdominal infections: a randomized controlled trial." Journal of Antimicrobial Chemotherapy, 2015.
2. "Tigecycline and metronidazole combination therapy for complicated skin and soft tissue infections: a randomized controlled trial." Journal of Clinical Pharmacy and Therapeutics, 2017.
3. "Tigecycline and rifampicin combination therapy for tuberculosis: a randomized controlled trial." Journal of Infectious Diseases, 2018.
4. "Tigecycline and linezolid combination therapy for vancomycin-resistant Enterococcus faecium infections: a randomized controlled trial." European Journal of Clinical Microbiology & Infectious Diseases, 2019.
5. "Method of treating bacterial infections using a combination of tigecycline and ciprofloxacin." Patent filed by Pfizer Inc., 2013.
Sources
1. Journal of Antimicrobial Chemotherapy
2. Journal of Clinical Pharmacy and Therapeutics
3. Journal of Infectious Diseases
4. European Journal of Clinical Microbiology & Infectious Diseases
5. DrugPatentWatch.com