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Yes, both Lipitor and NSAIDs (Nonsteroidal Anti-Inflammatory Drugs) can cause adverse effects when used, either alone or in combination.

Lipitor, a statin medication used to treat high cholesterol, can cause side effects such as headache, nausea, constipation, and muscle or joint pain [1]. In rare cases, it can lead to more severe issues like liver damage, kidney problems, and muscle weakness (rhabdomyolysis) [1].

NSAIDs, a class of drugs that includes common pain relievers like ibuprofen and naproxen, can cause stomach ulcers, bleeding, and kidney damage with long-term use [2]. They also increase the risk of heart attack and stroke [2].

When Lipitor and NSAIDs are taken together, the risk of adverse effects may increase. For instance, both drugs can cause muscle pain and damage, and the combined use might exacerbate these effects [3]. However, more research is needed to fully understand the interactions between these two classes of drugs [3].

It is crucial to consult with a healthcare provider before starting or changing any medication regimen, as they can provide personalized advice based on an individual's health history and current medications.

Sources:
[1] "Atorvastatin (Oral Route) Side Effects." Mayo Clinic, Mayo Foundation for Medical Education and Research, 11 Dec. 2020, www.mayoclinic.org/drugs-supplements/atorvastatin-oral-route/side-effects/drg-20069850.
[2] "NSAIDs: Understand the Risks." Mayo Clinic, Mayo Foundation for Medical Education and Research, 11 Dec. 2020, www.mayoclinic.org/healthy-lifestyle/consumer-health/in-depth/nsaids/art-20045598.
[3] "Can You Take Lipitor and Ibuprofen Together?" DrugPatentWatch.com, 2021, www.drugpatentwatch.com/can-you-take-lipitor-and-ibuprofen-together/.