See the DrugPatentWatch profile for lipitor

When it comes to the potency of Lipitor, also known as atorvastatin, and whether it changes when tablets are split, the information available suggests that the drug's efficacy should not be significantly affected by splitting the tablet. However, it's important to note that this may depend on several factors, including the specific dosage and the reason for splitting the tablet.

The U.S. Food and Drug Administration (FDA) states that some tablets can be split safely, as long as they are scored, or have a groove that makes them easy to split [1]. Lipitor tablets are scored, which means they can be split. However, the FDA also notes that splitting tablets may lead to inconsistent doses, which could potentially impact the drug's efficacy [1].

Meanwhile, Drugs.com states that Lipitor tablets can be split, and that splitting the tablet in half will result in a 10 mg dose if the original tablet was a 20 mg dose [2]. However, Drugs.com also notes that splitting tablets may lead to dosing errors and that it is important to consult with a healthcare provider before splitting any medication [2].

It's worth noting that Lipitor is available in a variety of dosages, including 10 mg, 20 mg, 40 mg, and 80 mg [3]. Therefore, it may be possible to avoid splitting the tablet altogether by using a dosage that is appropriate for the individual's needs.

In summary, while Lipitor tablets can be split, it's important to consult with a healthcare provider before doing so, as splitting tablets may lead to inconsistent doses and potential dosing errors.

Sources:
[1] U.S. Food and Drug Administration. (n.d.). Spliting (Splitting) Medication. Retrieved from <https://www.fda.gov/drugs/resources-information-approved-drugs/splitting-medication>
[2] Drugs.com. (2021). Atorvastatin. Retrieved from <https://www.drugs.com/atorvastatin.html>
[3] DrugPatentWatch. (n.d.). Lipitor (Atorvastatin Calcium). Retrieved from <https://www.drugpatentwatch.com/drugs/lipitor>