See the DrugPatentWatch profile for advil

There is limited research directly comparing the long-term use of Advil (ibuprofen) and its impact on liver damage between obese and non-obese individuals. However, some studies have explored the connection between obesity, non-steroidal anti-inflammatory drugs (NSAIDs) like Advil, and liver health.

A study published in the Journal of Clinical Gastroenterology found that obese individuals have a higher risk of developing non-alcoholic fatty liver disease (NAFLD) compared to non-obese individuals [1]. NAFLD is a condition characterized by an accumulation of fat in liver cells, which can lead to inflammation and scarring of the liver.

Additionally, research has shown that NSAID use can increase the risk of liver injury and dysfunction [2]. However, it is important to note that the risk of liver damage from NSAIDs is generally low, and most cases of liver injury are associated with other factors, such as pre-existing liver disease or the use of multiple medications [3].

While there is no direct evidence comparing the long-term use of Advil between obese and non-obese individuals and its impact on liver damage, it is reasonable to assume that obese individuals may have a higher risk of liver damage due to their increased risk of NAFLD and the potential interaction between obesity and NSAID use.

In summary, obese individuals may have a higher risk of liver damage from long-term Advil use due to their increased risk of NAFLD and the potential interaction between obesity and NSAID use. However, more research is needed to fully understand the relationship between obesity, Advil use, and liver damage.

Sources:

1. [Evaluation of Obesity as a Risk Factor for Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852745/). Journal of Clinical Gastroenterology.
2. [Nonsteroidal anti-inflammatory drugs and liver injury](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954587/). Expert Review of Clinical Pharmacology.
3. [Nonsteroidal Anti-Inflammatory Drug-Induced Liver Injury](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3761342/). Clinics in Liver Disease.
4. [Ibuprofen - Drug Patent Watch](https://www.drugpatentwatch.com/drugs/ibuprofen). DrugPatentWatch.com.