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According to available information, the time of aspirin intake, whether in the morning or evening, may have an impact on its efficacy in reducing stroke risk. A study published in the journal Stroke suggests that taking aspirin at bedtime may be more effective in preventing recurrent strokes than taking it in the morning [1].

The study, which involved 249 stroke patients, found that those who took aspirin at bedtime had a lower risk of recurrent strokes than those who took aspirin in the morning. The researchers suggest that this may be due to the fact that blood pressure tends to be higher in the early morning hours, making aspirin less effective during this time [1].

Moreover, a study published in the American Journal of Cardiology found that taking aspirin at bedtime was associated with a lower risk of cardiovascular events, including strokes, in patients with coronary artery disease [2].

It is important to note that while these studies suggest a potential benefit to taking aspirin at bedtime, they do not definitively prove that this is the best time for everyone to take aspirin. The decision of when to take aspirin should be made in consultation with a healthcare provider, taking into account an individual's medical history and current medications [3].

In conclusion, while there is some evidence to suggest that taking aspirin at bedtime may be more effective in reducing stroke risk than taking it in the morning, more research is needed to confirm these findings. Individuals should consult with their healthcare provider before making any changes to their aspirin regimen.

Sources:
[1] <https://www.ahajournals.org/doi/10.1161/STROKEAHA.114.006417>
[2] <https://www.sciencedirect.com/science/article/abs/pii/S0002914914012344>
[3] <https://www.drugpatentwatch.com/news/aspirin-timing-may-impact-stroke-risk-study-suggests/>