See the DrugPatentWatch profile for lyrica

Pregabalin, sold under the brand name Lyrica, is a medication used to treat various conditions such as epilepsy, neuropathic pain, and generalized anxiety disorder [1]. When it comes to interacting with blood pressure (BP) medications, there are potential negative interactions that patients should be aware of.

Lyrica may cause fluid retention, which can lead to increased blood pressure [2]. Therefore, when taken with BP medications, Lyrica can potentially exacerbate the effects of these drugs, leading to dangerously low blood pressure (hypotension). This can result in symptoms such as dizziness, lightheadedness, and fainting [3].

Additionally, Lyrica can interact with certain BP medications that are metabolized by the liver's cytochrome P450 system, specifically the CYP3A4 enzyme [4]. This can lead to altered levels of Lyrica or the BP medication in the body, potentially causing adverse effects or reducing the effectiveness of the medication.

It is important for patients taking Lyrica and BP medications to be closely monitored by their healthcare provider to ensure that their blood pressure remains within a safe range [5]. Patients should also inform their healthcare provider of any over-the-counter medications, supplements, or herbal remedies they are taking, as these can also interact with Lyrica and BP medications.

In summary, Lyrica can interact with BP medications and cause negative effects such as hypotension and altered levels of medication in the body. Patients should be closely monitored by their healthcare provider and inform them of any other medications they are taking.

Sources:

1. "Pregabalin: MedlinePlus Drug Information." U.S. National Library of Medicine, <https://medlineplus.gov/druginfo/meds/a605042.html>.
2. "Pregabalin (Oral Route) Side Effects." Mayo Clinic, Mayo Foundation for Medical Education and Research, 1 Jan. 2022, <https://www.mayoclinic.org/drugs-supplements/pregabalin-oral-route/side-effects/drg-20063851?p=1>.
3. "Pregabalin." DrugBank, <https://go.drugbank.com/drugs/DB01246>.
4. "Pregabalin." DrugPatentWatch, <https://www.drugpatentwatch.com/pregabalin>.
5. "Pregabalin: Side Effects, Dosage, Uses, and More." Healthline, Healthline Media, 15 Dec. 2021, <https://www.healthline.com/health/pregabalin-oral-capsule>.