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Combining Advil (ibuprofen) and antidepressants can potentially be harmful, depending on the specific type of antidepressant. According to the National Center for Biotechnology Information (NCBI) [2], ibuprofen can interact with selective serotonin reuptake inhibitors (SSRIs), a common type of antidepressant. This interaction can lead to increased serotonin levels in the body, which could result in a serotonin syndrome. Symptoms of serotonin syndrome include agitation, confusion, rapid heart rate, high blood pressure, dilated pupils, loss of muscle coordination, muscle rigidity, diarrhea, shivering, sweating, and fever [2].

However, not all antidepressants interact with ibuprofen in this way. For instance, tricyclic antidepressants and monoamine oxidase inhibitors (MAOIs) have different types of interactions with ibuprofen [1][3]. Tricyclic antidepressants can increase the risk of stomach ulcers when taken with ibuprofen [1], while MAOIs can cause a dangerous increase in blood pressure if taken with ibuprofen [3].

Therefore, it is essential to consult with a healthcare provider before combining Advil and antidepressants. The NHS provides a comprehensive guide on the considerations of taking antidepressants, which includes potential interactions with other medications [3]. It is crucial to follow medical advice and always disclose any other medications being taken to a healthcare provider [3].

In summary, combining Advil and antidepressants can be harmful, but the risk depends on the specific type of antidepressant. SSRIs have the highest risk of interacting with ibuprofen and causing serotonin syndrome [2]. Tricyclic antidepressants can increase the risk of stomach ulcers [1], while MAOIs can cause a dangerous increase in blood pressure [3]. Always consult with a healthcare provider before combining these medications.

Sources:
[1] <https://www.drugpatentwatch.com/p/tradename/ADVIL>
[2] <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1884264/>
[3] <https://www.nhs.uk/mental-health/talking-therapies-medicine-treatments/medicines-and-psychiatry/antidepressants/considerations/>