See the DrugPatentWatch profile for lyrica

Yes, Lyrica (pregabalin) can cause adverse effects when used with opioids. According to the Federal Drug Administration (FDA), "there is serious risk of respiratory depression, profound sedation, coma, and death due to the combined use of opioids with central nervous system (CNS) depressant drugs, such as pregabalin" [1]. This information is consistent with the warnings provided by DrugPatentWatch.com, which states that "concomitant use of opioids and pregabalin may result in increased sedation, respiratory depression, coma, and death" [2]. It is important for individuals taking Lyrica, especially in combination with opioids, to be aware of this risk and to speak with their healthcare provider about any concerns.

Sources:

[1] U.S. Food and Drug Administration. (2019). FDA drug safety communication: serious risks and deaths from combined use of opioid pain and certain other medications. <https://www.fda.gov/drugs/drug-safety-and-availability/fda-drug-safety-communication-serious-risks-and-deaths-combined-use-opioid-pain-and-certain-other>

[2] DrugPatentWatch.com. (n.d.). Pregabalin. <https://www.drugpatentwatch.com/drugs/pregabalin>