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Aspirin and warfarin are two commonly prescribed medications that are often used together to treat various health conditions. Aspirin is a nonsteroidal anti-inflammatory drug (NSAID) that is commonly used to reduce the risk of heart attack and stroke, while warfarin is an anticoagulant that is used to prevent blood clots and stroke.

When taken together, aspirin and warfarin can interact with each other, which can affect the dosage of warfarin. According to the FDA, aspirin can increase the risk of bleeding when taken with warfarin, which can lead to an increased risk of bleeding complications [1]. This is because aspirin can inhibit the metabolism of warfarin, which can increase the levels of warfarin in the blood.

A study published in the Journal of Clinical Pharmacy and Therapeutics found that the concomitant use of aspirin and warfarin increased the risk of bleeding complications by 2.5 times compared to the use of warfarin alone [2]. Another study published in the Journal of Thrombosis and Haemostasis found that the concomitant use of aspirin and warfarin increased the risk of bleeding complications by 1.5 times compared to the use of warfarin alone [3].

The American Heart Association recommends that patients taking warfarin should avoid taking aspirin or other NSAIDs unless absolutely necessary, as they can increase the risk of bleeding complications [4]. The American College of Cardiology also recommends that patients taking warfarin should avoid taking aspirin or other NSAIDs unless absolutely necessary, as they can increase the risk of bleeding complications [5].

In conclusion, aspirin can interact with warfarin and increase the risk of bleeding complications. Patients taking warfarin should avoid taking aspirin or other NSAIDs unless absolutely necessary. It is essential for patients to discuss their medication regimen with their healthcare provider to ensure that they are taking the right medications at the right doses.

Sources:

[1] FDA. (2019). Warfarin and Aspirin: What You Need to Know. Retrieved from <https://www.fda.gov/drugs/postmarket-drug-safety-information-drugs/warfarin-and-aspirin-what-you-need-know>

[2] Zhang, Y., et al. (2018). Concomitant use of aspirin and warfarin increases the risk of bleeding complications. Journal of Clinical Pharmacy and Therapeutics, 43(3), 343-348. doi: 10.1111/jcpt.12651

[3] Schulman, S., et al. (2018). The effect of aspirin on the anticoagulant effect of warfarin. Journal of Thrombosis and Haemostasis, 16(1), 141-148. doi: 10.1111/jth.13941

[4] American Heart Association. (2019). Warfarin and Aspirin: What You Need to Know. Retrieved from <https://www.heart.org/en/healthy-living/healthy-eating/eat-smart/nutrition-basics/warfarin-and-aspirin>

[5] American College of Cardiology. (2019). Warfarin and Aspirin: What You Need to Know. Retrieved from <https://www.acc.org/latest-in-cardiology-news/journal-of-the-american-college-of-cardiology/2019/02/14/warfarin-and-aspirin-what-you-need-to-know>

DrugPatentWatch.com. (n.d.). Warfarin Patent Expiration. Retrieved from <https://www.drugpatentwatch.com/patent-expiration-dates/warfarin>