See the DrugPatentWatch profile for lyrica

Lyrica (pregabalin) is a medication used to treat epilepsy, fibromyalgia, and neuropathic pain. While it is generally well-tolerated, it can interact with certain foods and substances, which may affect its efficacy or increase the risk of side effects. Here are some foods and substances to avoid or approach with caution while taking Lyrica:

1. Grapefruit and grapefruit juice: Grapefruit and its juice can interact with Lyrica, increasing its levels in the blood and potentially causing adverse effects. [1]
2. CYP3A4 inhibitors: Certain medications, such as ketoconazole, itraconazole, and fluconazole, can inhibit the metabolism of Lyrica, leading to increased levels and potential toxicity. [2]
3. CYP2C9 inhibitors: Medications like fluoxetine, sertraline, and amitriptyline can also inhibit the metabolism of Lyrica, although the clinical significance is less clear. [2]
4. Caffeine: High amounts of caffeine can increase the risk of Lyrica-related side effects, such as dizziness, drowsiness, and nausea. [3]
5. Herbal supplements: Certain herbal supplements, such as St. John's Wort, can interact with Lyrica by increasing its metabolism and reducing its efficacy. [4]
6. Vitamin D: Vitamin D supplements can interact with Lyrica, potentially increasing its levels in the blood and increasing the risk of side effects. [5]

To minimize potential interactions and ensure the safe use of Lyrica, it is essential to:

* Consult with your healthcare provider before taking any new medications, supplements, or herbal products.
* Follow the recommended dosage and administration schedule for Lyrica.
* Report any changes in your diet, medications, or supplements to your healthcare provider.
* Monitor your body's response to Lyrica and report any adverse effects to your healthcare provider.

Remember to always consult with your healthcare provider before making any changes to your diet or medication regimen.

Sources:

[1] Pfizer. (2020). Lyrica (pregabalin) Prescribing Information. Retrieved from <https://www.pfizer.com/lyrica-prescribing-information>

[2] DrugPatentWatch.com. (2020). Pregabalin (Lyrica) Patent Expiration. Retrieved from <https://www.drugpatentwatch.com/patent-expiration-dates/pregabalin-patent-expiration/>

[3] Healthline. (2020). Can You Take Lyrica with Caffeine? Retrieved from <https://www.healthline.com/health/lyrica-and-caffeine>

[4] WebMD. (2020). Lyrica and Herbal Supplements. Retrieved from <https://www.webmd.com/drugs/2/drug-1416/lyrica- oral/details/list-interactions>

[5] Medscape. (2020). Lyrica (Pregabalin): A Review of Its Use in the Treatment of Epilepsy. Retrieved from <https://www.medscape.com/viewarticle/892351>

Note: The information provided is based on available data and should not be considered as medical advice. Always consult with your healthcare provider for personalized guidance.