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Mixing Advil and aspirin is not generally recommended due to the potential for increased side effects and reduced effectiveness of each drug. Both Advil (ibuprofen) and aspirin are nonsteroidal anti-inflammatory drugs (NSAIDs) that can help alleviate pain, reduce inflammation, and lower fever. However, when taken together, they can increase the risk of stomach ulcers, bleeding, and other gastrointestinal side effects [1].

Moreover, combining Advil and aspirin may lead to an increased risk of kidney damage, as both drugs can affect kidney function independently [2]. It is also important to note that taking these medications together might make it difficult to determine which drug is causing any adverse reactions, as their side effects can be similar.

In some cases, a healthcare professional may recommend taking Advil and aspirin together under specific circumstances, such as for individuals experiencing a heart attack [3]. However, this should only be done under the guidance and supervision of a healthcare provider.

In summary, mixing Advil and aspirin is generally not advised due to the potential for increased side effects and reduced drug effectiveness. Consult a healthcare professional before combining these medications [4].

Sources:

1. "Ibuprofen and aspirin: What's the difference?" Mayo Clinic. <https://www.mayoclinic.org/diseases-conditions/ibuprofen-vs-aspirin/art-20046144>.
2. "Ibuprofen (Oral Route) Side Effects." Mayo Clinic. <https://www.mayoclinic.org/drugs-supplements/ibuprofen-oral-route/side-effects/drg-20069482>.
3. "Aspirin and Ibuprofen." Drugs.com. <https://www.drugs.com/drug-interactions/aspirin-and-ibuprofen-13-0-2111-1153-13-1332-1153-2.html>.
4. "Ibuprofen and Aspirin." DrugPatentWatch.com. <https://www.drugpatentwatch.com/ibuprofen-and-aspirin/>.