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High liver enzymes can indicate liver damage or inflammation, which is a concern during the use of tigecycline, a last-resort antibiotic. According to the prescribing information, tigecycline can cause elevations in liver enzymes, including aspartate aminotransferase (AST) and alanine aminotransferase (ALT) [1]. These enzymes are typically low in number in a healthy liver, but their levels increase when the liver is damaged or inflamed. Consequently, monitoring liver function is crucial during tigecycline treatment.

Elevated liver enzymes during tigecycline use may necessitate dose adjustments or treatment discontinuation, depending on the severity of the liver damage and the patient's overall health. Healthcare providers should be vigilant for signs of liver toxicity and consider alternative antibiotics if tigecycline is contraindicated [1].

In summary, high liver enzymes matter during tigecycline use because they can indicate liver damage or inflammation, which may require dose adjustments or treatment discontinuation. Monitoring liver function is essential during tigecycline treatment.

Sources:

[1] Tigecycline (Tygacil) prescribing information. U.S. Food and Drug Administration. <https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021867s013s014lbl.pdf>