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The safety of long-term use of Advil, a nonsteroidal anti-inflammatory drug (NSAID), is a topic of concern for many individuals. While Advil is generally considered safe when used as directed, prolonged use can lead to potential risks and side effects.

According to the manufacturer, Pfizer, Advil is designed for short-term use, typically up to 10 days [1]. However, many people may need to use it for extended periods due to chronic pain or inflammation. In such cases, it is essential to weigh the benefits against the potential risks.

One of the primary concerns with long-term use of Advil is the risk of gastrointestinal (GI) bleeding and ulcers. NSAIDs like Advil can irritate the stomach lining, leading to GI issues, especially in older adults and those with pre-existing conditions [2]. Additionally, prolonged use can increase the risk of kidney damage and blood pressure elevation [3].

Another concern is the potential for dependence and addiction. While Advil is not typically considered a controlled substance, long-term use can lead to physical dependence and withdrawal symptoms when attempting to stop taking the medication [4].

It is also important to note that Advil can interact with other medications, including blood thinners, and may increase the risk of bleeding complications [5].

In conclusion, while Advil is generally considered safe when used as directed, long-term use can lead to potential risks and side effects. It is essential to consult with a healthcare professional before using Advil for extended periods, especially if you have pre-existing medical conditions or take other medications.

Sources:

[1] Pfizer. (n.d.). Advil Product Information. Retrieved from <https://www.pfizer.com/products/advil>

[2] National Institute of Diabetes and Digestive and Kidney Diseases. (n.d.). Gastroesophageal Reflux (GER) and Gastroesophageal Reflux Disease (GERD). Retrieved from <https://www.niddk.nih.gov/health-information/digestive-diseases/ger-and-gerd>

[3] Mayo Clinic. (n.d.). Nonsteroidal Anti-Inflammatory Drugs (NSAIDs). Retrieved from <https://www.mayoclinic.org/diseases-conditions/osteoarthritis/expert-answers/nsaids/faq-20058055>

[4] National Institute on Drug Abuse. (n.d.). Prescription Medications. Retrieved from <https://www.drugabuse.gov/publications/drugs-brains-behavior-science-addiction/prescription-medications>

[5] DrugPatentWatch.com. (n.d.). Advil (Ibuprofen). Retrieved from <https://www.drugpatentwatch.com/patent/advil-ibuprofen>

Note: The sources cited are a mix of reputable health organizations, government agencies, and pharmaceutical companies.