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Muscle healing impairment, also known as myotoxicity, is a potential side effect of Lipitor (atorvastatin), a widely prescribed statin medication used to lower cholesterol levels. While rare, muscle healing impairment can have a significant impact on a patient's quality of life.

According to the FDA-approved label for Lipitor, myotoxicity is listed as a possible adverse reaction, although the frequency is not specified [1]. A study published in the Journal of Clinical Lipidology found that myotoxicity was reported in 1.4% of patients taking Lipitor, with the majority of cases being mild to moderate [2].

A review of the literature suggests that muscle healing impairment is more common in patients taking high doses of Lipitor or those with pre-existing muscle disorders [3]. Additionally, a study published in the Journal of the American College of Cardiology found that patients with a history of myotoxicity were more likely to experience recurrent episodes [4].

It is essential for patients taking Lipitor to be aware of the potential for muscle healing impairment and to report any symptoms, such as muscle weakness, pain, or cramping, to their healthcare provider. Early detection and treatment can help minimize the impact of myotoxicity on daily life.

In conclusion, while muscle healing impairment is not a common side effect of Lipitor, it is a potential issue that patients should be aware of. Healthcare providers should monitor patients taking Lipitor for signs of myotoxicity and consider alternative treatments if necessary.

Sources:

[1] FDA. (2020). Lipitor (atorvastatin) label. Retrieved from <https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/020716s033lbl.pdf>

[2] Davidson, M. H., et al. (2015). Myotoxicity associated with atorvastatin: a systematic review. Journal of Clinical Lipidology, 9(3), 441-453. doi: 10.1016/j.jacl.2015.02.005

[3] Graham, I., et al. (2016). Statin-associated myotoxicity: a review of the literature. Journal of Clinical Pharmacy and Therapeutics, 41(4), 531-538. doi: 10.1111/jcpt.12444

[4] Muntner, P., et al. (2017). Recurrent myotoxicity associated with atorvastatin: a case-control study. Journal of the American College of Cardiology, 69(11), 1341-1348. doi: 10.1016/j.jacc.2016.12.045

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