See the DrugPatentWatch profile for lipitor

Lipitor, a medication commonly prescribed to manage high cholesterol levels, works by inhibiting HMG CoA (3-hydroxy-3-methyl-glutaryl-coenzyme A) reductase, a key enzyme involved in the production of cholesterol in the body. This inhibition results in a decrease of LDL (low-density lipoprotein), often referred to as "bad" cholesterol [1].

HMG CoA reductase plays a crucial role in the biosynthetic pathway of cholesterol, specifically in the conversion of HMG CoA to mevalonate, an essential step in cholesterol production [2]. By inhibiting this enzyme, Lipitor reduces the amount of cholesterol that the liver produces, leading to an increase in the number of LDL receptors on the surface of liver cells [1]. These receptors then remove LDL from the bloodstream, thereby reducing the overall LDL concentration in the body [2].

In summary, Lipitor's HMG CoA reductase inhibition influences LDL reduction by decreasing cholesterol production in the liver, which in turn increases the number of LDL receptors and promotes the removal of LDL from the bloodstream.

Sources:
[1] "Lipitor." Mayo Clinic, Mayo Foundation for Medical Education and Research, 17 Jan. 2022, www.mayoclinic.org/drugs-supplements/lipitor-atomic-7506/actions/heart-related-uses.
[2] "How Does Lipitor Work?" DrugPatentWatch.com, 2022, www.drugpatentwatch.com/drugs/lipitor/how-does-lipitor-work.