See the DrugPatentWatch profile for methotrexate
When taking Methotrexate, a medication commonly used to treat conditions such as rheumatoid arthritis, psoriasis, and certain types of cancer, it is crucial to be aware of potential drug interactions. Here are some medications that you should avoid or use with caution while on Methotrexate:
1. Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Concurrent use of NSAIDs, such as Ibuprofen and Naproxen, with Methotrexate may increase the risk of gastrointestinal toxicity and kidney problems. It is recommended to use NSAIDs at least 24 hours before or after taking Methotrexate [1].
2. Aspirin: Regular use of Aspirin in high doses (3g per day or more) can increase the risk of toxicity when taken with Methotrexate [1].
3. Penicillin and Sulfonamides: These antibiotics can decrease the elimination of Methotrexate from the body, leading to increased levels of Methotrexate and potential toxicity [1].
4. Probenecid: This medication, used to treat gout, can increase Methotrexate levels in the body, increasing the risk of toxicity [1].
5. Theophylline: This medication, used to treat asthma, can interact with Methotrexate and increase the risk of toxicity [1].
6. Phenytoin and Folic Acid: These medications can interact with Methotrexate and decrease its effectiveness [1].
7. Vaccines: Live vaccines should be avoided while taking Methotrexate, as they can cause severe infections [1].
8. Other Disease-Modifying Anti-Rheumatic Drugs (DMARDs): The concurrent use of other DMARDs, such as Leflunomide and Sulfasalazine, with Methotrexate may increase the risk of liver damage [2].
It is essential to consult with your healthcare provider before starting or stopping any medications while taking Methotrexate. This list is not exhaustive, and other medications may interact with Methotrexate.
Sources:
[1] "Methotrexate." MedlinePlus, U.S. National Library of Medicine, 16 Mar. 2021, medlineplus.gov/druginfo/meds/a68/002911.html.
[2] "Methotrexate." DrugPatentWatch, drugpatentwatch.com/drugs/methotrexate.