See the DrugPatentWatch profile for lipitor

Yes, Lipitor (atorvastatin) can interact with anti-inflammatory drugs, specifically those that are classified as COX-2 inhibitors, such as celecoxib (Celebrex). This interaction can increase the risk of muscle damage (rhabdomyolysis) and kidney damage [1].

The interaction occurs due to the combined effect of these medications on the metabolism of certain drugs. Both atorvastatin and COX-2 inhibitors are metabolized by the cytochrome P450 system in the liver, specifically by the isoenzyme CYP3A4 [2]. When taken together, these drugs can compete for the same metabolic pathway, leading to increased levels of atorvastatin in the bloodstream [1].

As a result, the risk of adverse effects such as muscle pain, weakness, and kidney damage may be increased [1]. Patients taking both Lipitor and anti-inflammatory drugs should be closely monitored for any signs of muscle or kidney problems [1].

It is important to note that not all anti-inflammatory drugs interact with Lipitor in the same way. Non-selective NSAIDs, such as ibuprofen and naproxen, are less likely to interact with atorvastatin [1].

In summary, taking Lipitor with COX-2 inhibitors can increase the risk of adverse effects such as muscle and kidney damage. Patients taking both medications should be closely monitored for any signs of these problems.

Sources:

1. "atorvastatin and celecoxib interaction." Drugs.com, <https://www.drugs.com/drug-interactions/atorvastatin-and-celecoxib-interaction.html>.
2. "atorvastatin." DrugPatentWatch.com, <https://www.drugpatentwatch.com/drugs/atorvastatin>.
3. "atorvastatin and ibuprofen interaction." Drugs.com, <https://www.drugs.com/drug-interactions/atorvastatin-and-ibuprofen-interaction.html>.
4. "atorvastatin and naproxen interaction." Drugs.com, <https://www.drugs.com/drug-interactions/atorvastatin-and-naproxen-interaction.html>.