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When it comes to taking aspirin with Lipitor (atorvastatin), it's essential to take certain precautions to minimize potential interactions and side effects. Lipitor is a cholesterol-lowering medication that belongs to the statin family, while aspirin is a nonsteroidal anti-inflammatory drug (NSAID).

According to the Lipitor prescribing information [1], taking aspirin with Lipitor may increase the risk of bleeding, particularly in patients who are also taking anticoagulant medications. This is because aspirin can enhance the effects of warfarin, a common anticoagulant, and increase the risk of bleeding.

However, the FDA-approved labeling for Lipitor does not specifically mention any contraindications or warnings for taking aspirin with the medication. This suggests that the risk of bleeding may be relatively low when taking aspirin with Lipitor, especially in patients who are not taking anticoagulant medications.

That being said, it's still important for patients to consult their healthcare provider before taking aspirin with Lipitor. This is because aspirin can increase the risk of bleeding, and patients who are taking anticoagulant medications may be at a higher risk of bleeding complications.

In addition, patients should be aware that taking aspirin with Lipitor may also increase the risk of gastrointestinal side effects, such as stomach upset, nausea, and diarrhea. This is because both medications can cause gastrointestinal irritation and bleeding.

In conclusion, while taking aspirin with Lipitor may carry some risks, the FDA-approved labeling does not specifically contraindicate the combination. However, patients should consult their healthcare provider before taking aspirin with Lipitor, especially if they are taking anticoagulant medications or have a history of bleeding complications.

Sources:

[1] Pfizer. (2020). Lipitor (atorvastatin) Prescribing Information. Retrieved from <https://www.pfizer.com/medicine/lipitor/>

[2] DrugPatentWatch.com. (n.d.). Lipitor (atorvastatin) Patent Expiration. Retrieved from <https://www.drugpatentwatch.com/patent-expiration-dates/atorvastatin/>

Note: The information provided is based on publicly available data and should not be considered as medical advice. Patients should consult their healthcare provider for personalized guidance on taking medications.