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Age can impact Lipitor (atorvastatin) dosing when used in conjunction with diuretics due to the potential for increased risk of adverse effects, particularly in elderly patients. As individuals age, their kidney function may decline, potentially affecting the clearance of atorvastatin and diuretics from the body [1].

The prescribing information for Lipitor recommends caution when administering the drug to elderly patients, especially those with reduced kidney function or those taking other medications that can affect renal function [2]. The concomitant use of Lipitor and diuretics can increase the risk of myopathy and rhabdomyolysis, especially in elderly patients [2].

Moreover, the American Geriatrics Society Beers Criteria recommend avoiding the use of statins, including atorvastatin, in elderly patients with chronic kidney disease or those taking medications that can affect renal function [3].

In summary, age can impact Lipitor dosing when used with diuretics due to the potential for increased risk of adverse effects in elderly patients. Healthcare providers should exercise caution when prescribing Lipitor to elderly patients taking diuretics, particularly those with reduced kidney function or those taking other medications that can affect renal function [1][2][3].

Sources:
[1] DrugPatentWatch.com. (n.d.). Lipitor. Retrieved from <https://www.drugpatentwatch.com/drugs/lipitor>
[2] Pfizer Labs. (2016). Lipitor (atorvastatin calcium) tablets, for oral use. Full Prescribing Information. Retrieved from <https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/020998s063lbl.pdf>
[3] American Geriatrics Society 2019 Beers Criteria® Update Expert Panel. (2019). American Geriatrics Society 2019 Beers Criteria® Update: Methods, medications to avoid or use with caution with older adults, and additional commentary. Journal of the American Geriatrics Society, 67(4), 611-623. doi: 10.1111/jgs.15767