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Based on the available information, it is generally recommended to check liver function before starting Lipitor (atorvastatin) treatment and periodically thereafter [1]. This recommendation is primarily due to the potential for statins, a class of cholesterol-lowering medications that Lipitor belongs to, to affect liver function [1][2].

Lipitor works by inhibiting an enzyme called HMG-CoA reductase, which plays a crucial role in the production of cholesterol in the body [1]. Although uncommon, statins can cause elevations in liver enzymes, indicating potential liver damage [1]. However, it is important to note that these elevations are typically mild and asymptomatic, and most people can continue taking the medication without any issues [1].

Before starting Lipitor, a healthcare professional will typically order liver function tests (LFTs) to establish a baseline for comparison [1]. If the LFTs are abnormal, the healthcare professional may choose to monitor the patient more closely or consider alternative treatments [1].

In summary, while it is not always necessary to check liver function before starting Lipitor, it is generally recommended to do so as a precautionary measure [1]. Patients should consult their healthcare provider for personalized advice regarding their Lipitor treatment.

Sources:
[1] <https://www.drugs.com/lipitor.html>
[2] <https://www.mayoclinic.org/diseases-conditions/high-blood-cholesterol/in-depth/statins/art-20045786>
[3] <https://www.drugpatentwatch.com/drugs/lipitor>