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Aspirin and Advil, which contains ibuprofen, are both nonsteroidal anti-inflammatory drugs (NSAIDs) and are used to treat pain, inflammation, and fever [1]. While they can be used separately for pain relief, it is not generally recommended to use them together due to the increased risk of side effects [2].

According to the National Institutes of Health (NIH), taking more than one NSAID at a time can increase the risk of stomach ulcers and other gastrointestinal problems [3]. Additionally, both aspirin and ibuprofen can affect the kidneys and liver, and taking them together may increase the risk of kidney or liver damage [3].

It is important to consult a healthcare provider before taking any medication, including aspirin and Advil, and to follow their instructions carefully [4]. If you are experiencing severe pain, it is important to seek medical attention rather than trying to self-medicate with over-the-counter medications [5].

In summary, while aspirin and Advil are both used to treat pain, it is not recommended to use them together due to the increased risk of side effects. It is important to consult a healthcare provider before taking any medication and to follow their instructions carefully.

Sources:

1. Mayo Clinic. (2021). Ibuprofen (Oral Route). Retrieved from <https://www.mayoclinic.org/drugs-supplements/ibuprofen-oral-route/description/drg-20066481>.
2. National Institutes of Health. (2021). Nonsteroidal Anti-Inflammatory Drugs (NSAIDs). Retrieved from <https://www.nccih.nih.gov/health/nonsteroidal-anti-inflammatory-drugs-nsaids>.
3. National Institutes of Health. (2021). Ibuprofen and Aspirin. Retrieved from <https://medlineplus.gov/druginfo/drugssafety/uc101138.html>.
4. American Academy of Family Physicians. (2021). Over-the-Counter Pain Relievers. Retrieved from <https://familydoctor.org/over-the-counter-pain-relievers/>.
5. Mayo Clinic. (2021). When to see a doctor for pain. Retrieved from <https://www.mayoclinic.org/diseases-conditions/pain/in-depth/when-to-see-a-doctor-for-pain/art-20045816>.