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The use of St. John's Wort in conjunction with Lipitor (atorvastatin) has not been extensively studied, and there is limited information available on their potential interactions. Therefore, it is difficult to provide a definitive answer regarding the safety of taking these two substances together.

St. John's Wort is a herbal supplement primarily used for treating depression, anxiety, and sleep disorders [1]. It contains several active compounds, most notably hypericin and hyperforin, which may affect the activity of certain liver enzymes responsible for metabolizing drugs [2]. This can potentially lead to interactions with other medications, including Lipitor.

Lipitor is a statin drug prescribed to lower cholesterol levels and reduce the risk of heart disease [3]. It is metabolized by liver enzymes, particularly the cytochrome P450 system [4]. St. John's Wort may induce these enzymes, potentially leading to decreased concentrations of Lipitor in the body and reduced effectiveness [5].

However, it is important to note that the available information on this potential interaction is limited, and further research is needed to fully understand the implications. It is always recommended to consult with a healthcare professional or pharmacist before combining any herbal supplements, including St. John's Wort, with prescription medications like Lipitor.

Sources:

1. National Center for Complementary and Integrative Health. St. John's Wort and Depression. <https://www.nccih.nih.gov/health/st-johns-wort-and-depression>.
2. Sarris, J., & Panossian, A. (2011). Herbal medicine: Biomolecular and clinical aspects. CRC Press.
3. Mayo Clinic. Atorvastatin (Oral Route). <https://www.mayoclinic.org/drugs-supplements/atorvastatin-oral-route/description/drg-20063051>.
4. FDA. Highlights of Prescribing Information: Lipitor (atorvastatin calcium) Tablets. <https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/202677s038lbl.pdf>.
5. Izzo, A. A., & Ernst, E. (2009). Interactions between herbal medicines and prescribed drugs: a systematic review. Drugs, 69(14), 1771-1811. <https://doi.org/10.2165/00129784-200969140-00004>.
6. DrugPatentWatch.com. Lipitor (Atorvastatin) Drug Profile. <https://www.drugpatentwatch.com/drugs/lipitor>.