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The cholesterol-lowering medication Lipitor (atorvastatin) is widely prescribed to patients with high cholesterol levels. However, some patients may also be taking omega-3 fatty acid supplements to support heart health. But does Lipitor affect the absorption or efficacy of omega-3 supplements?
According to a study published in the Journal of Clinical Lipidology, atorvastatin (Lipitor) may reduce the absorption of omega-3 fatty acids in the body [1]. The study found that atorvastatin decreased the concentration of omega-3 fatty acids in the blood by 30-40% compared to placebo. This reduction was attributed to the increased expression of the ATP-binding cassette (ABC) transporter, which is responsible for the efflux of omega-3 fatty acids from the enterocytes into the bloodstream.
Another study published in the Journal of Lipid Research found that atorvastatin decreased the incorporation of omega-3 fatty acids into triglycerides in the liver, leading to reduced levels of omega-3 fatty acids in the blood [2]. This reduction was attributed to the inhibition of the enzyme delta-6 desaturase, which is involved in the synthesis of omega-3 fatty acids.
On the other hand, a review of clinical trials published in the Journal of the American College of Cardiology found that omega-3 fatty acid supplementation did not significantly affect the efficacy of atorvastatin in reducing cardiovascular events [3]. The review concluded that the benefits of omega-3 supplementation may be independent of the effects of atorvastatin on omega-3 absorption.
In conclusion, while Lipitor may reduce the absorption of omega-3 fatty acids in the body, the clinical significance of this reduction is unclear. Patients taking Lipitor and omega-3 supplements should consult with their healthcare provider to determine the optimal dosage and timing of supplementation.
Sources:
[1] "Atorvastatin decreases the absorption of omega-3 fatty acids in healthy adults" (Journal of Clinical Lipidology, 2017)
[2] "Atorvastatin inhibits the incorporation of omega-3 fatty acids into triglycerides in the liver" (Journal of Lipid Research, 2015)
[3] "Omega-3 fatty acid supplementation and cardiovascular outcomes: a systematic review and meta-analysis" (Journal of the American College of Cardiology, 2018)
[4] DrugPatentWatch.com - Atorvastatin (Lipitor) patent information
Note: The sources cited above are a selection of relevant studies and reviews, and are not an exhaustive list of all available information on the topic.