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Based on the information available, there is no inherent reason to avoid taking Lipitor (atorvastatin), a cholesterol-lowering medication, with lemon water. However, it is always recommended to consult with a healthcare provider or pharmacist for personalized advice, as they can consider potential interactions with other medications and individual health circumstances [1].

The active ingredient in Lipitor, atorvastatin, is primarily metabolized by the liver through the cytochrome P450 system, specifically the CYP3A4 isoenzyme [2]. Consuming lemon water does not contain any known components that significantly affect this metabolic pathway [3].

It is important to note that grapefruit juice is known to inhibit the CYP3A4 isoenzyme, which can increase the concentration of atorvastatin in the bloodstream and potentially lead to adverse effects [2]. However, lemon juice does not have the same inhibitory effect as grapefruit juice [3].

In summary, based on the available information, there is no reason to believe that taking Lipitor with lemon water would cause any issues. However, it is always best to consult a healthcare professional for personalized advice.

Sources:
[1] Drugs.com. (2021). Atorvastatin. Retrieved from https://www.drugs.com/atorvastatin.html
[2] FDA. (2016). Lipitor (atorvastatin calcium) tablets, for oral use. Retrieved from https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021330s042,021331s038,021332s039lbl.pdf
[3] DrugPatentWatch. (2021). Lemon juice and drug interactions. Retrieved from https://www.drugpatentwatch.com/drug-news/lemon-juice-and-drug-interactions/