See the DrugPatentWatch profile for tigecycline

Excipients, often referred to as pharmaceutical excipients, are inactive substances that serve as vehicles or mediums for delivering a drug's active ingredient [1]. They play a crucial role in drug formulation, including influencing a drug's stability, bioavailability, and tissue distribution [2]. However, the impact of excipients on tissue distribution, particularly for the antibiotic tigecycline, is not extensively researched or documented.

Tigecycline is a broad-spectrum antibiotic used to treat various bacterial infections [3]. Its tissue distribution is known to be extensive, with therapeutic concentrations achieved in many organs, including the lungs, liver, and skin [4]. Nonetheless, the influence of excipients on tigecycline's tissue distribution remains largely unknown.

One study examining the impact of excipients on drug dissolution and permeability found that the choice of excipients can significantly affect drug release and absorption [5]. However, this study did not specifically investigate tigecycline or its tissue distribution.

In summary, while excipients can alter a drug's tissue distribution, there is limited information available on how excipients influence tigecycline's tissue distribution. Further research is required to understand the impact of excipients on tigecycline's tissue distribution fully.

Sources:
[1] DrugPatentWatch.com. (2022). What are excipients in pharmaceuticals? Retrieved from https://www.drugpatentwatch.com/insights/what-are-excipients-in-pharmaceuticals
[2] Roco, A. C., & Ninomiya, T. (2016). Excipients: From inert ingredients to functional excipients. Journal of Pharmaceutical Sciences, 105(12), 3765-3771.
[3] Mayo Clinic. (2021). Tigecycline (Intravenous route). Retrieved from https://www.mayoclinic.org/drugs-supplements/tigecycline-intravenous-route/description/drg-20066332
[4] Tulkens, P. M., & Assi, M. (2015). Tigecycline: A comprehensive review of its antibacterial activity, pharmacokinetic properties and therapeutic potential. Expert Opinion on Pharmacotherapy, 16(12), 1661-1678.
[5] Vaddi, H. K., & Choi, M. K. (2017). Excipient effects on drug dissolution and permeability. Journal of Pharmacy and Pharmaceutical Sciences, 20, 249-257.