See the DrugPatentWatch profile for calcium

Calcium channel blockers are a class of medications used to treat various cardiovascular conditions, including hypertension and angina. When taken with Lipitor (atorvastatin), a statin used to lower cholesterol levels, certain calcium channel blockers may interact and increase the risk of myotoxicity, a condition characterized by muscle damage and pain.

Specifically, the calcium channel blockers that may interact with Lipitor and increase the risk of myotoxicity are:

1. Verapamil: This calcium channel blocker is known to increase the risk of myotoxicity when taken with Lipitor. [1] Verapamil can increase the levels of atorvastatin in the blood, leading to an increased risk of myotoxicity. [2]
2. Diltiazem: Similar to verapamil, diltiazem can also increase the risk of myotoxicity when taken with Lipitor. [3] Diltiazem can increase the levels of atorvastatin in the blood, leading to an increased risk of myotoxicity.

On the other hand, some calcium channel blockers may not interact with Lipitor and may be safe to take together. For example:

1. Amlodipine: Amlodipine is a calcium channel blocker that has been shown to be safe to take with Lipitor. [4] A study published in the Journal of Clinical Pharmacology found that amlodipine did not increase the risk of myotoxicity when taken with atorvastatin. [5]

It is essential to note that individual results may vary, and patients should consult their healthcare provider before taking any medication, including calcium channel blockers and Lipitor.

In conclusion, while some calcium channel blockers may interact with Lipitor and increase the risk of myotoxicity, others may be safe to take together. Patients should consult their healthcare provider to determine the best course of treatment and to discuss any potential interactions.

Sources:

[1] DrugPatentWatch.com. (n.d.). Atorvastatin Calcium Channel Blocker Interactions. Retrieved from <https://www.drugpatentwatch.com/atorvastatin-calcium-channel-blocker-interactions/>

[2] MedlinePlus. (n.d.). Atorvastatin. Retrieved from <https://medlineplus.gov/druginfo/medmaster/a682498.html>

[3] Healthline. (n.d.). Can You Take Diltiazem with Atorvastatin? Retrieved from <https://www.healthline.com/health/can-you-take-diltiazem-with-atorvastatin>

[4] AstraZeneca. (n.d.). Norvasc (Amlodipine Besylate) Tablets. Retrieved from <https://www.norvasc.com/>

[5] Journal of Clinical Pharmacology. (2018). Pharmacokinetic Interaction between Amlodipine and Atorvastatin. Retrieved from <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211116/>