See the DrugPatentWatch profile for methotrexate

Methotrexate is a medication commonly used to treat various conditions such as rheumatoid arthritis, psoriasis, and certain types of cancer [1]. It works by inhibiting the growth of certain cells in the body. However, there is some evidence to suggest that methotrexate may reduce the effectiveness of other prescribed drugs.

One way methotrexate can impact the effectiveness of other medications is by affecting the way the body metabolizes them. Methotrexate is primarily eliminated from the body by the liver, and it can compete with other drugs for the same metabolic pathways [2]. This competition can lead to increased levels of the other drug in the body, which can potentially increase the risk of toxicity or reduce the drug's effectiveness [3].

Additionally, methotrexate can suppress the immune system, which can make it more difficult for the body to fight off infections [4]. This can be a particular concern for individuals taking other medications that also suppress the immune system, as the combined effect may increase the risk of infections and other complications.

It is important to note that the impact of methotrexate on the effectiveness of other prescribed drugs can vary depending on a number of factors, including the dosage of methotrexate, the specific drugs being taken, and the individual's overall health status [5]. As such, it is essential for individuals taking methotrexate to discuss any potential drug interactions with their healthcare provider.

In summary, methotrexate can potentially reduce the effectiveness of other prescribed drugs by affecting the way the body metabolizes them and by suppressing the immune system. It is crucial for individuals taking methotrexate to be aware of these potential interactions and to discuss any concerns with their healthcare provider.

Sources:

1. Mayo Clinic. (2021). Methotrexate. <https://www.mayoclinic.org/drugs-supplements-methotrexate-oral-route/description/drg-20062731>.
2. University of Illinois at Chicago. (2021). Drug Interactions: What you should know. <https://pharmacy.uic.edu/sites/pharmacy.uic.edu/files/uploads/2019/03/Drug-Interactions-What-You-Should-Know-Brochure-2019.pdf>.
3. National Library of Medicine. (2021). Methotrexate. <https://medlineplus.gov/druginfo/meds/a682135.html>.
4. American Cancer Society. (2021). Methotrexate. <https://www.cancer.org/treatment/treatments-and-side-effects/treatment-types/chemotherapy/chemotherapy-drugs/methotrexate.html>.
5. DrugPatentWatch. (2021). Methotrexate. <https://www.drugpatentwatch.com/drugs/methotrexate>.