See the DrugPatentWatch profile for lipitor

Lipitor, a medication commonly used to treat high cholesterol, works by inhibiting the HMG-CoA reductase enzyme. This enzyme plays a crucial role in the production of cholesterol in the body. Lipitor specifically binds to the active site of HMG-CoA reductase, preventing the enzyme from catalyzing the reaction that leads to cholesterol production [1].

The binding of Lipitor to HMG-CoA reductase inhibits the conversion of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) to mevalonic acid, which is a key step in the biosynthesis of cholesterol [2]. By inhibiting this step, Lipitor helps to reduce the overall levels of cholesterol in the body, thereby lowering the risk of heart disease and stroke.

It is important to note that Lipitor is a highly specific and targeted medication, and its mechanism of action is well understood. The drug's ability to bind to the active site of HMG-CoA reductase is what makes it an effective treatment for high cholesterol [3].

In summary, Lipitor specifically binds to the active site of HMG-CoA reductase, inhibiting the enzyme's ability to catalyze the reaction that leads to cholesterol production. This is what makes Lipitor an effective treatment for high cholesterol.

Sources:
[1] "Lipitor (atorvastatin)". Drugs.com. <https://www.drugs.com/lipitor.html>.
[2] "HMG-CoA reductase". Genetics Home Reference. <https://medlineplus.gov/genetics/gene/hmgcr/>.
[3] "Atorvastatin". DrugPatentWatch.com. <https://www.drugpatentwatch.com/drugs/atorvastatin>.