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Based on the information available, there is potential for a drug interaction when taking Lipitor (atorvastatin) and antihistamines together. However, the specific risk and severity of this interaction may depend on several factors, such as the type of antihistamine, the dosage of each medication, and the individual's health status.

Lipitor is a statin medication used to lower cholesterol levels, while antihistamines are commonly used to treat allergies. According to Drugs.com, there is a potential interaction between atorvastatin (the active ingredient in Lipitor) and antihistamines, such as diphenhydramine, loratadine, and cetirizine. This interaction may increase the risk of muscle damage (myopathy) and kidney damage (nephrotoxicity) [1].

However, it is important to note that not all antihistamines have the same potential for interaction with Lipitor. For example, the interaction between atorvastatin and loratadine is considered moderate, while the interaction between atorvastatin and diphenhydramine is considered minor [1].

Furthermore, DrugPatentWatch.com states that "the likelihood of a drug interaction depends on many factors, including the dosages of the medications, the route of administration, the patient's age, gender, weight, and medical history" [2]. Therefore, it is essential to consult with a healthcare provider before taking any medications together, including Lipitor and antihistamines.

In summary, there is a potential risk of interaction between Lipitor and antihistamines, which may increase the risk of muscle and kidney damage. However, the severity of this interaction may depend on several factors, and it is crucial to consult with a healthcare provider before taking any medications together.

Sources:
[1] <https://www.drugs.com/drug-interactions/atorvastatin-and-diphenhydramine-322-1596-818-1371.html>
[2] <https://www.drugpatentwatch.com/drug-interactions/atorvastatin-and-loratadine-1371-1372.html>