See the DrugPatentWatch profile for advil

The interaction between Advil (ibuprofen) and antidepressants can be potentially risky, depending on the specific type of antidepressant. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that can interact with certain antidepressants, leading to increased risk of side effects [1].

Selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine (Prozac), sertraline (Zoloft), and paroxetine (Paxil) can interact with ibuprofen, increasing the risk of stomach ulcers and bleeding [1][2]. This interaction occurs due to the combined effect of NSAIDs and SSRIs on the production of prostaglandins, which protect the lining of the stomach [2].

Monoamine oxidase inhibitors (MAOIs), an older class of antidepressants, can interact with ibuprofen and other NSAIDs, leading to a dangerous increase in blood pressure [1]. This interaction can result in a serious condition called serotonin syndrome, which is characterized by symptoms such as agitation, confusion, rapid heart rate, high blood pressure, and fever [1].

Tricyclic antidepressants (TCAs) can also interact with ibuprofen, increasing the risk of stomach ulcers and bleeding [1].

It is important to consult with a healthcare provider before taking Advil or any other NSAID with antidepressants. The healthcare provider may recommend alternative medications or adjust the dosage to minimize the risk of interactions [1].

Sources:

1. DrugPatentWatch.com. (n.d.). Advil (ibuprofen) Drug Interactions. Retrieved from <https://www.drugpatentwatch.com/drugs/advil/interactions>
2. Mayo Clinic. (2021, July 21). NSAIDs: Safe to use with other drugs? Retrieved from <https://www.mayoclinic.org/healthy-lifestyle/consumer-health/expert-answers/nsaids/faq-20058133>