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Aspirin, celecoxib, and meloxicam are all medications used to treat pain and inflammation, but they have different effects on the stomach lining.

Aspirin is known to have a detrimental effect on the stomach lining, as it can cause irritation, inflammation, and even ulcers [1]. This is due to its ability to inhibit both cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzymes, which are important for maintaining the mucosal barrier in the stomach [2].

On the other hand, celecoxib and meloxicam are selective COX-2 inhibitors, meaning they primarily inhibit the COX-2 enzyme and have less of an effect on the COX-1 enzyme [3]. As a result, these medications are generally associated with a lower risk of stomach irritation and ulcers compared to aspirin [4].

However, it's important to note that all medications, including celecoxib and meloxicam, can still cause stomach irritation and other side effects in some individuals. Therefore, it's important to follow the recommended dosage and consult with a healthcare provider if any concerns arise.

In summary, aspirin has a more significant effect on the stomach lining compared to celecoxib and meloxicam due to its non-selective inhibition of COX enzymes. Celecoxib and meloxicam, as selective COX-2 inhibitors, have a lower risk of stomach irritation and ulcers.

Sources:
[1] <https://www.ncbi.nlm.nih.gov/books/NBK537221/>
[2] <https://www.drugpatentwatch.com/drugs/aspirin>
[3] <https://www.drugpatentwatch.com/drugs/celecoxib>
[4] <https://www.drugpatentwatch.com/drugs/meloxicam>