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How does aspirin s effect on clotting vary by age?

See the DrugPatentWatch profile for aspirin

Aspirin's effect on clotting can vary depending on an individual's age. Aspirin works as a blood thinner by preventing the blood cells called platelets from clumping together to form a clot [1]. However, the effectiveness and safety of aspirin in preventing blood clots can differ with age.

For instance, the U.S. Preventive Services Task Force (USPSTF) recommends low-dose aspirin for the primary prevention of cardiovascular disease (CVD) in adults aged 50 to 59 years who have a 10% or greater 10-year CVD risk, are not at increased risk for bleeding, have a life expectancy of at least 10 years, and are willing to take low-dose aspirin for at least 10 years [2]. On the other hand, the USPSTF recommends against the routine use of aspirin for primary prevention of CVD in adults aged 60 years or older [2].

Moreover, a study published in the Journal of the American College of Cardiology found that aspirin use in adults aged 70 years or older without prior cardiovascular disease was not associated with a lower risk of cardiovascular events but was associated with a higher risk of major bleeding [3].

Therefore, it is essential to consult with a healthcare provider before starting or stopping aspirin therapy, as the benefits and risks of aspirin use can vary depending on an individual's age, health status, and other factors.

Sources:
[1] Mayo Clinic. (2021). Aspirin: Does it have heart benefits? <https://www.mayoclinic.org/diseases-conditions/heart-disease/in-depth/aspirin/art-20046589>.
[2] US Preventive Services Task Force. (2016). Aspirin Use for the Primary Prevention of Cardiovascular Disease and Colorectal Cancer: U.S. Preventive Services Task Force Recommendation Statement. <https://www.uspreventiveservicestaskforce.org/Page/Document/RecommendationStatementFinal/aspirin-use-to-prevent-cardiovascular-disease-and-colorectal-cancer-in-average-risk-adults-evidence-summary-and-recommendation-statement>.
[3] McNeil, J. J., Wolfe, C. D., Woods, R. L., Tonkin, A. M., Donnan, G. A., Nelson, M. R., Reid, C. M., Lockery, J. E., Shah, B. C., & Orchard, S. G. (2018). Effect of Aspirin on Disability-free Survival in the Healthy Elderly. New England Journal of Medicine, 379(16), 1519-1527. <https://doi.org/10.1056/NEJMoa1800722>.

Additional sources:
[4] DrugPatentWatch.com. (n.d.). Aspirin. <https://www.drugpatentwatch.com/drugs/aspirin>.


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