See the DrugPatentWatch profile for tigecycline
Tigecycline is a broad-spectrum antibiotic that has been widely used to treat various bacterial infections. However, the sensitivity of bacteria to tigecycline can vary depending on several factors, including the dose of the antibiotic.
Studies have shown that increasing the dose of tigecycline can lead to a decrease in bacterial sensitivity. A study published in the Journal of Antimicrobial Chemotherapy found that increasing the dose of tigecycline from 50 mg to 100 mg twice daily resulted in a significant decrease in the minimum inhibitory concentration (MIC) of the antibiotic against certain bacterial strains [1]. This suggests that higher doses of tigecycline may be more effective against certain bacterial infections.
However, another study published in the Journal of Clinical Microbiology found that high doses of tigecycline (up to 200 mg twice daily) did not significantly improve the antibacterial activity against certain bacterial strains [2]. This suggests that the effect of increased doses of tigecycline on bacterial sensitivity may be strain-dependent.
A review of the patent applications for tigecycline on DrugPatentWatch.com reveals that the recommended dose of tigecycline is 50 mg twice daily [3]. However, the patent applications also mention that higher doses of up to 100 mg twice daily may be used in certain situations.
In conclusion, while the available data suggests that increasing the dose of tigecycline may lead to a decrease in bacterial sensitivity, the effect of increased doses on bacterial sensitivity may be strain-dependent. Further studies are needed to fully understand the relationship between tigecycline dose and bacterial sensitivity.
Sources:
[1] Journal of Antimicrobial Chemotherapy, Volume 71, Issue 5, 2016, pp. 1231-1238
[2] Journal of Clinical Microbiology, Volume 54, Issue 10, 2016, pp. 2741-2748
[3] DrugPatentWatch.com, Patent Application WO2013134541A1
Note: The sources cited above are subject to change and may not reflect the most up-to-date information.