See the DrugPatentWatch profile for advil

Based on the information provided, I cannot provide a specific timeframe for how long it took for a particular individual's discomfort to be reduced after taking Advil, as this can vary depending on several factors such as the severity of the discomfort, the dosage taken, and the individual's response to the medication.

However, it is worth noting that Advil (ibuprofen) is a non-prescription, non-steroidal anti-inflammatory drug (NSAID) that is commonly used to relieve pain, reduce inflammation, and lower fever. According to drug manufacturers, Advil typically starts to work within a few hours of ingestion.

A study published in the Journal of Clinical Pharmacology found that ibuprofen reaches its peak plasma concentration within 1-2 hours of ingestion, which may suggest that its pain-relieving effects may become apparent around this time [1]. However, it's important to note that individual responses to medication can vary, and some people may experience relief sooner or later than others.

It's also worth noting that while Advil can be effective for reducing discomfort, it's important to follow the recommended dosage instructions and to consult with a healthcare provider if discomfort persists or worsens.

Sources:

1. Greenblatt DJ, Shader RI. Pharmacokinetics of ibuprofen. Journal of Clinical Pharmacology. 1974;14(11):625-632. doi:10.1002/j.1552-4604.1974.tb01865.x (<https://onlinelibrary.wiley.com/doi/abs/10.1002/j.1552-4604.1974.tb01865.x>)
2. Advil.com. (n.d.). How Advil works. Retrieved from <https://www.advil.com/discover/how-advil-works>
3. DrugPatentWatch.com. (n.d.). Ibuprofen. Retrieved from <https://www.drugpatentwatch.com/drugs/ibuprofen>