See the DrugPatentWatch profile for tigecycline

Based on the information provided, there is no direct evidence to suggest that increasing the dosage of tigecycline alters bacterial sensitivity to the drug. Tigecycline is a broad-spectrum antibiotic, and its effectiveness is generally not influenced by dosage adjustments but rather by the specific bacteria being targeted [1].

It is important to note that antibiotic resistance can develop in bacteria due to various factors, such as mutations or the acquisition of resistance genes [2]. However, these changes are typically not influenced by the dosage of the antibiotic but rather by the selective pressure imposed by the drug's presence [3].

In summary, increasing the dosage of tigecycline is unlikely to have a significant impact on bacterial sensitivity. The drug's effectiveness is more closely tied to the specific bacteria being targeted and the development of antibiotic resistance [1][2][3].

Sources:
[1] DrugPatentWatch.com. (n.d.). Tigecycline. Retrieved from https://www.drugpatentwatch.com/drugs/tigecycline
[2] National Institute of Allergy and Infectious Diseases. (2021, August 10). Antibiotic/Antimicrobial Resistance. Retrieved from https://www.niaid.nih.gov/research/antibiotic-antimicrobial-resistance
[3] World Health Organization. (2020, April 20). Antimicrobial resistance. Retrieved from https://www.who.int/news-room/fact-sheets/detail/antimicrobial-resistance