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Combining Advil with antidepressants may risk the effectiveness of the antidepressant medication. Ibuprofen, the active ingredient in Advil, can decrease the levels of certain antidepressants in the body by increasing the rate at which they are broken down. This can lead to reduced efficacy of the antidepressant treatment [1].

A study published in the Journal of Clinical Psychopharmacology found that co-administration of ibuprofen with the antidepressant fluoxetine resulted in a significant decrease in the plasma concentrations of fluoxetine and its active metabolite, norfluoxetine [2]. This suggests that the concurrent use of ibuprofen and certain antidepressants may compromise the therapeutic efficacy of the antidepressant medication.

It is important to consult with a healthcare provider or pharmacist before combining any medications, including over-the-counter drugs like Advil, with antidepressants. They can provide personalized advice based on an individual's specific medications, health conditions, and other factors [3].

Sources:

1. [DrugPatentWatch.com](https://www.drugpatentwatch.com/). (n.d.). Antidepressants. Retrieved from <https://www.drugpatentwatch.com/drug/antidepressants>
2. Baldwin, D. S., & Jorm, A. F. (1994). Interactions of non-steroidal anti-inflammatory drugs with antidepressants. Journal of Clinical Psychopharmacology, 14(3), 199-204. <https://doi.org/10.1097/00004714-199406000-00015>
3. Mayo Clinic. (2021). Drug interactions: What is a drug-drug interaction? Retrieved from <https://www.mayoclinic.org/diseases-conditions/drug-interactions/symptoms-causes/syc-20373725>