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Mixing Advil (ibuprofen) with antidepressants can potentially lead to stomach issues. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that can irritate the lining of the stomach and cause stomach ulcers or bleeding, especially when taken in high doses or for long periods [1]. Certain antidepressants, particularly selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs), can also increase the risk of stomach problems [2].

When Advil and antidepressants are taken together, the risk of stomach issues may be higher due to the potential interaction between the two types of medications [3]. The interaction can increase the amount of time that ibuprofen stays in the body, which can increase the risk of stomach irritation and bleeding [4].

It is important to note that not all antidepressants will interact with Advil in the same way, and the risk of stomach issues may depend on the specific antidepressant and the dosage of both medications [5]. Therefore, it is crucial to consult with a healthcare provider before taking Advil with antidepressants to determine the potential risks and appropriate dosages [6].

In summary, mixing Advil and antidepressants can lead to stomach issues due to the potential interaction between the two types of medications. It is essential to consult with a healthcare provider before taking these medications together to determine the potential risks and appropriate dosages.

Sources:

1. Mayo Clinic. (2021). Ibuprofen (Oral Route). Retrieved from <https://www.mayoclinic.org/drugs-supplements/ibuprofen-oral-route/side-effects/drg-20069630?p=1>
2. National Institute of Mental Health. (2021). Antidepressants. Retrieved from <https://www.nimh.nih.gov/health/topics/antidepressants-for-children-and-adolescents/index.shtml#part_154754>
3. DrugBank. (2021). Ibuprofen. Retrieved from <https://go.drugbank.com/drugs/DB00323>
4. DrugPatentWatch. (2021). Ibuprofen. Retrieved from <https://www.drugpatentwatch.com/drugs/ibuprofen>
5. American Academy of Family Physicians. (2019). Nonsteroidal Anti-Inflammatory Drugs (NSAIDs). Retrieved from <https://familydoctor.org/nonsteroidal-anti-inflammatory-drugs-nsaids/>
6. American Society of Health-System Pharmacists. (2021). Ibuprofen. Retrieved from <https://medlineplus.gov/druginfo/meds/a682035.html>