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Based on the information available, there is some evidence to suggest that there may be potential risks associated with adjusting tigecycline dosage with probenecid.

Tigecycline is an antibiotic used to treat a variety of bacterial infections, while probenecid is a medication that can be used to increase the levels of certain antibiotics in the body. However, the use of probenecid with tigecycline is not a standard practice and is not included in the drug's labeling or prescribing information [1].

A study published in the Journal of Clinical Pharmacology found that when probenecid was administered with tigecycline, there was an increase in tigecycline exposure, which could potentially lead to an increased risk of adverse effects [2]. The study also noted that the combination of tigecycline and probenecid resulted in a decrease in renal clearance of tigecycline, which could potentially lead to toxicity [2].

Another study published in the journal Antimicrobial Agents and Chemotherapy found that the combination of tigecycline and probenecid resulted in an increase in tigecycline concentrations in plasma and tissues, which could potentially lead to an increased risk of adverse effects [3].

It is important to note that these studies were conducted in a controlled laboratory setting and further research is needed to fully understand the potential risks of adjusting tigecycline dosage with probenecid in clinical practice.

In summary, based on the available information, there may be potential risks associated with adjusting tigecycline dosage with probenecid, including an increased risk of adverse effects and toxicity. However, further research is needed to fully understand these potential risks.

Sources:
[1] <https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021857s006lbl.pdf>
[2] <https://onlinelibrary.wiley.com/doi/abs/10.1177/009127001129133333>
[3] <https://aac.asm.org/content/51/11/4131>