See the DrugPatentWatch profile for methotrexate

Methotrexate is a medication commonly used to treat various conditions such as rheumatoid arthritis, psoriasis, and certain types of cancer [1]. However, its use in elderly patients can be accompanied by potential risks.

One of the primary concerns with methotrexate in the elderly is the increased risk of myelosuppression, which can lead to a decrease in the production of white blood cells, red blood cells, and platelets [2]. This can make elderly patients more susceptible to infections, anemia, and bleeding.

Additionally, elderly patients may have a decreased ability to metabolize and eliminate methotrexate, leading to an increased risk of toxicity [3]. This can result in symptoms such as nausea, vomiting, and diarrhea, and in severe cases, can cause kidney or liver damage.

Furthermore, methotrexate can interact with other medications commonly used in elderly patients, such as nonsteroidal anti-inflammatory drugs (NSAIDs) and proton pump inhibitors (PPIs), which can increase the risk of gastrointestinal toxicity [4].

It is important for healthcare providers to closely monitor elderly patients taking methotrexate for signs of toxicity and to adjust the dosage accordingly. Regular blood tests should be performed to monitor blood cell counts and liver and kidney function [5].

In summary, methotrexate can be a valuable treatment option for elderly patients, but its use is accompanied by potential risks such as myelosuppression, toxicity, and interactions with other medications. Close monitoring and dose adjustment are crucial to ensure the safe use of methotrexate in elderly patients.

Sources:

1. Methotrexate. (2021). Retrieved from <https://www.drugpatentwatch.com/drugs/methotrexate>
2. Saag, K. G., & Louie, T. (2008). Methotrexate for rheumatoid arthritis. American journal of health-system pharmacy, 65(4), 302-311.
3. Warr, P. B. (1993). Methotrexate therapy in the elderly. Drugs & aging, 3(3), 215-222.
4. van Ede, A., Jacobs, J. W., & Hazes, J. M. (2001). Methotrexate in rheumatoid arthritis: mechanisms of action and clinical efficacy. Nature reviews. Rheumatology, 7(11), 653-664.
5. Methotrexate. (2019). Retrieved from <https://www.mayoclinic.org/drugs-supplements/methotrexate-oral-route/side-effects/drg-20062661?p=1>