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The interaction between Advil (ibuprofen) and antidepressants can potentially have negative effects on the body. Advil is a nonsteroidal anti-inflammatory drug (NSAID) that can increase the risk of bleeding when taken with certain antidepressants like selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs). This combination can lead to a higher chance of gastrointestinal bleeding or bruising. It is important to consult with a healthcare provider before taking these medications together to avoid adverse effects on your health [3].

Furthermore, the National Institute on Alcohol Abuse and Alcoholism (NIAAA) highlights the importance of being cautious with medication interactions, especially when it comes to mixing alcohol with medications. While not directly related to Advil and antidepressants, this resource emphasizes the need for awareness of potential dangerous interactions that can occur when combining different substances [2].

In summary, the combination of Advil and antidepressants can have negative interactions in the body, particularly increasing the risk of bleeding. It is crucial to seek advice from a healthcare professional to ensure safe and effective use of these medications together [3].

Sources:
[2] https://www.niaaa.nih.gov/health-professionals-communities/core-resource-on-alcohol/alcohol-medication-interactions-potentially-dangerous-mixes
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8298645/